JYNNEOS (also known as Imvamune or Imvanex) is a vaccine licensed by the U.S. Food and Drug Administration (FDA) to prevent monkeypox and can be used before and after exposure to monkeypox.

  • CDC recommends vaccination for people who have been exposed to monkeypox and people who are at higher risk of being exposed to monkeypox. 
  • JYNNEOS is given in a 2 dose series. 
  • If given before exposure or within 4 days of exposure, this vaccine may reduce the likelihood of infection, and within 14 days, it may reduce severity of symptoms.

ECDOH Monkeypox Vaccination Clinics 

Current Eligibility 

  • Those at high risk of a recent exposure to monkeypox, including gay men and members of the bisexual, transgender, and gender non-conforming community and other communities of men who have sex with men and who have engaged in intimate or skin-to-skin contact with others.
  • Individuals who have had skin-to-skin contact with someone in a social network experiencing monkeypox activity, including men who have sex with men who meet partners through an online website, digital application ("app"), or social event, such as a bar or party.
  • Individuals with recent exposure to a suspected or confirmed monkeypox case within the past 14 days should call the ECDOH Epidemiology Office at 716-858-7697.

Vaccine Clinics

1st Dose & 2nd Dose Clinic:

  • Monday - Friday 
    9:00 am - 3:00 pm
    Jesse Nash Health Center
    608 William St
    Buffalo, NY 14206 
    Register Here; Walk-ins are also welcome

1st Dose Only Clinic:

  • October 6, 2022
    10:00 am - 4:00 pm
    The Belle Center
    104 Maryland St
    Buffalo, NY 14201

    Register Here; Walk-ins are also welcome

    2nd Dose Only Clinics:

    • Please see the chart below to determine when to return for your 2nd dose. 
    • Individuals are considered to be fully vaccinated about 2 weeks after their 2nd dose of JYNNEOS.
    Date that You Received Your 1st Dose
    Date to Return for Your 2nd Dose
    Clinic Hours
    8/30/2022 10/4/2022 1:00 pm - 5:00 pm Evergreen on Bailey, 3297 Bailey Ave, Buffalo, NY 14215
    9/9/2022 10/14/2022 10:30 am - 4:30 pm  Delavan Grider Community Center, 877 E Delavan Ave, Buffalo, NY 14215
    10/6/2022 11/10/2022 10:00 am - 4:00 pm The Belle Center, 104 Maryland St, Buffalo, NY 14201

    More information about Monkeypox Vaccine

    What is Monkeypox? 

    Monkeypox is a rare disease caused by infection with the monkeypox virus. Monkeypox virus is part of the same family of viruses as smallpox. Monkeypox symptoms are similar to smallpox symptoms, but milder and monkeypox is rarely fatal. Monkeypox is not related to chickenpox.

    Symptoms of Monkeypox
    • Flu-like symptoms such as fever, headache, muscle aches, chills, swollen lymph nodes and fatigue. These symptoms may occur before or after the rash appears, or not at all. 
    • A rash that
      • can look like pimples or blisters that appears on the face, inside the mouth, and on other body parts like the hands, feet, chest, genitals, or anus. 
      • The rash goes through different stages before healing completely.
      • View examples of monkeypox rashes here.
    • The illness typically lasts 2-4 weeks.
    How Monkeypox is Spread

    Monkeypox is spread through close, physical contact between individuals. This includes:

    • Direct contact with monkeypox sores or rashes on an individual who has monkeypox.
    • Respiratory droplets or oral fluids from someone with monkeypox, particularly for those who have close contact with someone or are around them for a long period of time.
    • It can also be spread through contact with objects or fabrics (e.g., clothing, bedding, towels) that have been used by someone with monkeypox.
    • Ask your sexual partners whether they have a rash or other symptoms consistent with monkeypox.
    • Avoid close, skin-to-skin contact with people who have a rash that looks like monkeypox.
    • Do not touch the rash or scabs of a person with monkeypox. 
    • Do not kiss, hug, cuddle or have sex with someone with monkeypox. 
    • Do not share eating utensils or cups with a person with monkeypox. 
    • Do not handle or touch the bedding, towels, or clothing of a person with monkeypox. 
    • Wash your hands often with soap and water or use an alcohol-based hand sanitizer. 
    • In Central and West Africa, avoid contact with animals that can spread monkeypox virus, usually rodents and primates. Also, avoid sick or dead animals, as well as bedding or other materials they have touched. 
    • If you are sick with monkeypox: 
      • Isolate at home 
      • If you have an active rash or other symptoms, stay in a separate room or area away from people or pets you live with, when possible.
    For Healthcare Providers


    09/26/2022 - 10:40 am